Molecular Mechanism of Porcine Epidemic Diarrhea Virus Cell Tropism
Zhiwei Li, Zhiqian Ma, Linfang Dong, Ting Yang, Yang Li, Dian Jiao, Weiguo Han, Haixue Zheng, Shuqi Xiao
Abstract
adaptation to Vero cells. These results illustrate the decisive role of PEDV S protein in cell tropism and highlight the potential role of coronaviruses S protein in cross-species transmissibility. Besides, our finding also provides some unique insight into identifying PEDV functional receptors and has guiding significance for developing PEDV and other coronavirus vaccines.
Topics & Concepts
TropismVirologyMechanism (biology)Porcine epidemic diarrhea virusVirusDiarrheaBiologyMicrobiologyMedicineInternal medicinePhilosophyEpistemologyAnimal Virus Infections StudiesViral gastroenteritis research and epidemiologyVirus-based gene therapy research