Design of Orally-bioavailable Tetra-cyclic phthalazine SOS1 inhibitors with high selectivity against EGFR
Huan He, Ruiqi Chen, Ziwei Wang, Luolong Qing, Yu Zhang, Yi Liu, Weidong Pan, Huaxiang Fang, Silong Zhang, Silong Zhang
Topics & Concepts
KRASPhthalazineChemistryCancer researchRegulatorIn vivoCarcinogenesisPharmacologyMutationBiochemistryBiologyBiotechnologyGeneOrganic chemistryCancer therapeutics and mechanismsBiochemical and Molecular ResearchHER2/EGFR in Cancer Research