Breast cancer-derived CAV1 promotes lung metastasis by regulating integrin α6β4 and the recruitment and polarization of tumor-associated neutrophils
Qing Lin, Siwen Zong, Yi Wang, Youjia Zhou, Keqin Wang, Fuxiu Shi, Jiayang Wang, Mingrui Feng, Wenting Luo, Lifang Zhang, Hui Lin, Lixia Xiong
Abstract
. In this study, we showed that CAV1 increases the likelihood that BC lung metastasis would occur by controlling the expression of integrin α6β4 and via boosting TANs recruitment and polarization through activating the TLR4-NF-B-IL-6/CCL2 and TLR4/NF-B/NLRP3 signaling pathways. According to our findings, CAV1 regulates integrin α6β4 and modulates TLR4 signaling, both of which are critical for BC lung metastasis. This finding may open new avenues for BC lung metastasis prevention and treatment.
Topics & Concepts
MetastasisBreast cancerCancer researchLung cancerIntegrinMedicineBiologyCancerInternal medicineOncologyReceptorCell Adhesion Molecules ResearchImmune Response and InflammationImmune cells in cancer