Metal-Free C–S Bond Formation in Elemental Sulfur and Cyclobutanol Derivatives: The Synthesis of Substituted Thiophenes
Mingzhong Wu, Chaoxian Yan, Daijiao Zhuang, Rulong Yan
Abstract
-cyclobutanols and elemental sulfur has been developed. This protocol provides a strategy for constructing multisubstituted thiophene derivatives via C-S bond formation under air. This reaction shows good functionality tolerance under the reaction conditions, and the mechanism is validated by control experiments and density functional theory calculations.
Topics & Concepts
ChemistrySulfurMetalCombinatorial chemistryPolymer chemistryOrganic chemistrySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions