Synthesis of 2-aminobenzofurans <i>via</i> base-mediated [3 + 2] annulation of <i>N</i>-phenoxy amides with <i>gem</i>-difluoroalkenes
Kaifeng Chen, Weijie Chen, Fangyuan Chen, Haiman Zhang, Huiying Xu, Zhi Zhou, Wei Yi
Abstract
Efficient metal-free [3 + 2] annulation of <italic>N</italic>-phenoxy amides with <italic>gem</italic>-difluoroalkenes has been realized for the assembly of 2-aminobenzofuran derivatives with potent cytotoxicity against cancer cell lines and application potential for DELs.
Topics & Concepts
AnnulationChemistryStereochemistryBase (topology)Combinatorial chemistryCytotoxicityOrganic chemistryCatalysisMathematicsBiochemistryIn vitroMathematical analysisCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions