Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones
Wen‐Bo Liu, Jun Guo, Shipei Xing, Zhan Lu
Abstract
A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.
Topics & Concepts
HydroborationChemistryEnantioselective synthesisCobaltCatalysisImidazoleChiral ligandPhthalideLigand (biochemistry)Functional groupCombinatorial chemistryOrganic chemistryStereochemistryReceptorBiochemistryPolymerAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryChemical Synthesis and Analysis