CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Kun Leng, Indigo V.L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero‐Fernandez, Brenda L. Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell C. Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, Michael V. Sofroniew, Stephen P.J. Fancy, Matthew Schrag, Ethan S. Lippmann, Martin Kampmann
Topics & Concepts
NeuroscienceNeuroinflammationBiologyAstrocyteInflammationCentral nervous systemImmunologyNeuroinflammation and Neurodegeneration MechanismsCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics