Litcius/Paper detail

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

Kun Leng, Indigo V.L. Rose, Hyosung Kim, Wenlong Xia, Wilber Romero‐Fernandez, Brenda L. Rooney, Mark Koontz, Emmy Li, Yan Ao, Shinong Wang, Mitchell C. Krawczyk, Julia TCW, Alison Goate, Ye Zhang, Erik M. Ullian, Michael V. Sofroniew, Stephen P.J. Fancy, Matthew Schrag, Ethan S. Lippmann, Martin Kampmann

2022Nature Neuroscience160 citationsDOIOpen Access PDF

Topics & Concepts

NeuroscienceNeuroinflammationBiologyAstrocyteInflammationCentral nervous systemImmunologyNeuroinflammation and Neurodegeneration MechanismsCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics