Catalyst- and solvent-free efficient access to <i>N</i>-alkylated amines <i>via</i> reductive amination using HBpin
Vipin K. Pandey, Somnath Bauri, Arnab Rit
Abstract
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules.
Topics & Concepts
Reductive aminationAminationCatalysisAlkylationSolventSteric effectsChemistryCombinatorial chemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisOrganoboron and organosilicon chemistry