Design, synthesis, and anticancer evaluation of N-sulfonylpiperidines as potential VEGFR-2 inhibitors, apoptotic inducers
Walid E. Elgammal, Ahmed H. Halawa, Ibrahim H. Eissa, Hazem Elkady, Ahmed M. Metwaly, Saber M. Hassan, Ahmed M. El‐Agrody
Topics & Concepts
SorafenibChemistryIC50ApoptosisDoxorubicinCell cultureInducerIn vitroCytotoxicityHep G2Docking (animal)Flow cytometryPharmacologyCell cycleVinblastineCancer researchStereochemistryHepatocellular carcinomaMolecular biologyBiochemistryBiologyChemotherapyGeneMedicineNursingGeneticsAngiogenesis and VEGF in CancerSynthesis and biological activityCancer Mechanisms and Therapy