Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies
Manasa Kadagathur, G. Parimala Devi, Preeti Grewal, Dilep Kumar Sigalapalli, Priyanka N. Makhal, Uttam Chand Banerjee, Nagendra Babu Bathini, Neelima D. Tangellamudi
Topics & Concepts
CytotoxicityChemistryDAPITopoisomeraseHEK 293 cellsDNADocking (animal)ApoptosisMolecular biologyCell cultureBiochemistryIn vitroBiophysicsBiologyReceptorGeneticsNursingMedicineCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and bioactivity of alkaloids