Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
Andrew Frisch, Yiyang Wang, Bingxian Xie, Aaron Yang, B. Rhodes Ford, Supriya Joshi, Katarzyna M. Kedziora, Ronal M. Peralta, Drew N. Wilfahrt, Steven J. Mullett, Kellie Spahr, Konstantinos Lontos, Jessica A Jana, Victoria Dean, William Gunn, Stacy G. Wendell, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe
Topics & Concepts
Cancer immunotherapyIn vitroImmunotherapyFlux (metallurgy)Cancer researchCancerCancer cellEpigeneticsBiologyCell biologyChemistryBiochemistryGeneGeneticsOrganic chemistryCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction