Nanomedicine platform for targeting activated neutrophils and neutrophil–platelet complexes using an α1-antitrypsin-derived peptide motif
Michelle A. Cruz, Dillon Bohinc, Elizabeth Andraska, Jurgis Alvikas, Shruti Raghunathan, Nicole A. Masters, Nadine D. van Kleef, Kara L. Bane, Kathryn Hart, Kathryn Medrow, Michael Sun, Haitao Liu, Shannon Haldeman, Ankush Banerjee, Emma M. Lessieur, Kara Hageman, Agharnan Gandhi, Maria de la Fuente, Marvin T. Nieman, Timothy S. Kern, Coen Maas, Steven de Maat, Keith B. Neeves, Matthew D. Neal, Anirban Sen Gupta, Evi X. Stavrou
Topics & Concepts
In vivoNanomedicineIn vitroPeptideElastaseNeutrophil extracellular trapsNeutrophil elastaseTargeted drug deliveryDrugDrug deliveryPlatelet activationChemistryPlateletInflammationImmunologyMedicinePharmacologyMaterials scienceNanotechnologyBiologyBiochemistryNanoparticleEnzymeBiotechnologyNeutrophil, Myeloperoxidase and Oxidative MechanismsVasculitis and related conditionsComplement system in diseases