Vascular heterogeneity: VEGF receptors make blood vessels special
Pin Li, Napoleone Ferrara
Abstract
Karaman et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210565) examined the differential effects of the conditional deletion of genes encoding each VEGF receptor, VEGFR1, VEGFR2 and VEGFR 3, as well as combinations thereof in mice. The results highlight the crosstalk between receptors in different organs and emphasize the importance of VEGF receptor expression and interplay in vascular heterogeneity.
Topics & Concepts
ReceptorVEGF receptorsBiologyCrosstalkGeneCell biologyVascular endothelial growth factorKinase insert domain receptorCancer researchImmunologyGeneticsVascular endothelial growth factor AOpticsPhysicsAngiogenesis and VEGF in CancerAtherosclerosis and Cardiovascular DiseasesLymphatic System and Diseases