Discovery and optimization of selective RET inhibitors via scaffold hopping
Zhibo Luo, Lingli Wang, Zhifei Fu, Bin Shuai, Miaorong Luo, Guoping Hu, Jian Chen, Jikui Sun, Jiansong Wang, Jian Li, Shuhui Chen, Yang Zhang
Topics & Concepts
CabozantinibVandetanibChemistryKinaseCancer researchIC50Drug discoveryEGFR inhibitorsMutantPotencyGrowth inhibitionPharmacologyIn vitroTyrosine kinaseBiochemistryReceptorBiologyVEGF receptorsEpidermal growth factor receptorGeneCancer-related Molecular PathwaysCancer-related gene regulationUbiquitin and proteasome pathways