Rhodium-Catalyzed Deuterated Tsuji–Wilkinson Decarbonylation of Aldehydes with Deuterium Oxide
Xiang‐Ting Min, Yong‐Kang Mei, Bingzhi Chen, Li-Bowen He, Tingting Song, Ding‐Wei Ji, Yan‐Cheng Hu, Boshun Wan, Qing‐An Chen
Abstract
The recent surge in the applications of deuterated drug candidates has rendered an urgent need for diverse deuterium labeling techniques. Herein, an efficient Rh-catalyzed deuterated Tsuji–Wilkinson decarbonylation of naturally available aldehydes with D2O is developed. In this reaction, D2O not only acts as a deuterated reagent and solvent but also promotes Rh-catalyzed decarbonylation. In addition, decarbonylative strategies for the synthesis of terminal monodeuterated alkenes from α,β-unsaturated aldehydes are within reach.
Topics & Concepts
ChemistryDecarbonylationRhodiumDeuteriumCatalysisOxideOrganic chemistryQuantum mechanicsPhysicsChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis