Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype
Jane T. Jones, Ko-Wei Liu, Xi Wang, Caitlin H. Kowalski, Brandon S. Ross, K. Mills, Joshua D. Kerkaert, Tobias M. Hohl, Lotus Lofgren, Jason Stajich, Joshua J. Obar, Robert A. Cramer
Abstract
can be used not only to better understand disease pathogenesis of ABPA and potential antifungal treatments but also to identify features of fungal strains that drive long-term fungal persistence in the lung. Consequently, these observations are a step toward helping resolve the long-standing question of when to utilize antifungal therapies in patients with ABPA and fungal allergic-type diseases.
Topics & Concepts
Allergic bronchopulmonary aspergillosisAspergillus fumigatusCystic fibrosisAspergillusAspergillosisPulmonary aspergillosisLungImmunologyMedicineDiseasePhenotypeFungusMicrobiologyLung diseaseBiologyPathologyImmunoglobulin EAntibodyInternal medicineBotanyBiochemistryGeneAntifungal resistance and susceptibilityInfectious Diseases and MycologyNematode management and characterization studies