Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration
Krista M. Armbruster, Gloria Komazin, Timothy C. Meredith
Abstract
-2 ester to form a cyclic tetrahedral intermediate that then collapses to produce lyso-lipoprotein. Lit is a unique example of an intramolecular transacylase differentiated from that catalyzed by Lnt, and provides insight into the heterogeneity of bacterial lipoprotein biosynthetic systems.
Topics & Concepts
ChemistryBiochemistryThioesterCysteineStereochemistryActive siteDiacylglycerol kinaseEnzymeProtein kinase CStreptococcal Infections and TreatmentsRNA and protein synthesis mechanismsAntimicrobial Resistance in Staphylococcus