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PARP inhibition synergizes with CD47 blockade to promote phagocytosis by tumor-associated macrophages in homologous recombination-proficient tumors

Yangyang Liu, Rui Xue, Xixi Duan, Xiaoping Shang, Ming Wang, Fazhan Wang, Linyu Zhu, Lijing Zhang, Xin Ge, Xianlan Zhao, Hongjun Guo, Zhihong Wang, Lindong Zhang, Xiang Gao, Airong Shen, Yuqiao Sheng, Zhihai Qin

2023Life Sciences39 citationsDOI

Topics & Concepts

OlaparibCancer researchPARP inhibitorFlow cytometryIn vivoImmunotherapyTumor microenvironmentCancerMedicineImmune systemBiologyImmunologyPoly ADP ribose polymeraseInternal medicineTumor cellsPolymeraseBiochemistryBiotechnologyGenePARP inhibition in cancer therapyPhagocytosis and Immune RegulationCancer Immunotherapy and Biomarkers
PARP inhibition synergizes with CD47 blockade to promote phagocytosis by tumor-associated macrophages in homologous recombination-proficient tumors | Litcius