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Two telomere‐to‐telomere pig genome assemblies and pan‐genome analyses provide insights into genomic structural landscape and genetic adaptations

Wencheng Zong, Li Chen, Dongjie Zhang, Yuebo Zhang, Jinbu Wang, Jinbu Wang, Xinhua Hou, Jie Chai, Yalong An, Ming Tian, Xinmiao He, Chengyi Song, Jun He, Xin Liu, L X Wang, L X Wang, Enrico D’Alessandro, Lixian Wang, Lixian Wang, Yulong Yin, Mingzhou Li, Di Liu, Jinyong Wang, Jinyong Wang, Longchao Zhang

2025iMeta9 citationsDOIOpen Access PDF

Abstract

This study presented two high-precision telomere-to-telomere genome assemblies for Min and Rongchang pigs, including a detailed exploration of the telomeric and centromeric regions. By integrating pan-genome and multi-omics analyses, structural variations linked to genetic adaptation were identified, providing a valuable resource for advancing pig breeding and genetic improvement.

Topics & Concepts

TelomereGenomeBiologyGeneticsComputational biologyTelomeraseEvolutionary biologyGeneAnimal Genetics and ReproductionCRISPR and Genetic EngineeringChromosomal and Genetic Variations
Two telomere‐to‐telomere pig genome assemblies and pan‐genome analyses provide insights into genomic structural landscape and genetic adaptations | Litcius