An <i>Aspidosperma</i>-type alkaloid dimer from <i>Tabernaemontana bovina</i> as a candidate for the inhibition of microglial activation
Yang Yu, Simeng Zhao, Mei‐Fen Bao, Xiang‐Hai Cai
Abstract
As a representative of twelve undescribed <italic>Aspidosperma</italic>-type alkaloid dimers, tabernaemontine F (<bold>6</bold>) inhibited microglial activation by blocking P38 MAPK activation, revealing a potential candidate for chronic neurodegenerative diseases.
Topics & Concepts
AspidospermaChemistryAlkaloidDimerStereochemistryPharmacologyBiologyIndole testOrganic chemistryAlkaloids: synthesis and pharmacologyTraditional and Medicinal Uses of AnnonaceaeNatural product bioactivities and synthesis