New Chemical Modalities and Strategic Thinking in Early Drug Discovery
Marı́a-Jesús Blanco, Kevin M. Gardinier
Abstract
The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are now considered early in target appraisal. In this Viewpoint, we highlight recent progress in the field.
Topics & Concepts
ToolboxModalitiesDrug discoveryComputer scienceDrugData scienceTherapeutic modalitiesComputational biologyMedicineBioinformaticsPharmacologyBiologyInternal medicineProgramming languageSociologySocial scienceProtein Degradation and InhibitorsCAR-T cell therapy researchRNA Interference and Gene Delivery