A review of the known MTA-cooperative PRMT5 inhibitors
Mei Hu, Xiang Chen
Abstract
vulnerability of the aromatic amine moiety of the second-generation PRMT5 inhibitor based on its structure. It also considers the potential nitrosamine risk factors associated with the preparation process.
Topics & Concepts
Protein arginine methyltransferase 5MethyltransferaseEpigeneticsArginineChemistryPharmacologyMedicineBiochemistryMethylationAmino acidGeneCancer-related gene regulation