Population Pharmacokinetics and Monte Carlo Simulation for Dosage Optimization of Fosfomycin in the Treatment of Osteoarticular Infections in Patients without Renal Dysfunction
Matteo Rinaldi, Pier Giorgio Cojutti, Eleonora Zamparini, Sara Tedeschi, Nicolò Rossi, Matteo Conti, Maddalena Giannella, Federico Pea, Pierluigi Viale
Abstract
Fosfomycin is gaining interest in the treatment of complex osteoarticular infections (OI) due to multidrug-resistant (MDR) pathogens. Our aims were to conduct population pharmacokinetics of fosfomycin in a cohort of OI patients receiving 16 g daily by intermittent (II) or continuous (CI) infusion and to carry out Monte Carlo simulations for dosage optimization in the treatment of these infections.
Topics & Concepts
FosfomycinPharmacokineticsPopulation pharmacokineticsMedicineMonte Carlo methodPopulationPharmacologyIntensive care medicineAntibioticsMathematicsStatisticsBiologyMicrobiologyEnvironmental healthOrthopedic Infections and TreatmentsInfectious Diseases and TuberculosisPneumocystis jirovecii pneumonia detection and treatment