Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both
Guangzhi Ma, Yunfu Deng, Luxi Qian, Karin A. Vallega, Guojing Zhang, Xingming Deng, Taofeek K. Owonikoko, Suresh S. Ramalingam, Douglas D. Fang, Yifan Zhai, Shi‐Yong Sun
Topics & Concepts
OsimertinibApoptosisCancer researchBiologyIntrinsic apoptosisCytochrome cProgrammed cell deathCancerEpidermal growth factor receptorErlotinibBiochemistryCaspaseGeneticsLung Cancer Treatments and MutationsCancer Mechanisms and TherapyCell death mechanisms and regulation