Lens autophagy protein ATG16L1: a potential target for cataract treatment
Yilei Cui, Xiaoning Yu, Jing Bao, Xiyuan Ping, Silu Shi, Yuxin Huang, Qichuan Yin, Hao Yang, Ruoqi Chen, Ke Yao, Xiangjun Chen, Xingchao Shentu
Abstract
Our study identified an unrecognized mechanism of cataractogenesis involving ATG16L1 ubiquitination in autophagy regulation, offering new insights for treating cataracts.
Topics & Concepts
AutophagyCataractsMechanism (biology)ATG16L1BlindnessLens (geology)MedicineCataract surgeryCell biologyNeuroscienceOphthalmologyBiologyOptometryApoptosisBiochemistryPaleontologyEpistemologyPhilosophyConnexins and lens biologyAutophagy in Disease and TherapyVibrio bacteria research studies