A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis
Aneesh Ali, Chandrashekhar Jori, Kanika, Ajay Kumar, Akshay Vyawahare, J. Satish Kumar, Bhuvnesh Kumar, Anas Ahmad, Mohammad Fareed, Nemat Ali, Umashanker Navik, Rehan Khan
Abstract
-stearoyl-L-ascorbic acid (SAA), in promoting the production of collagen production through ten-eleven translocation-2 (TET2) upregulation. Targeting through NR4A1 and TET2 could be the probable mechanism for the treatment of experimental arthritis. The combination of 9AA and ascorbic acid demonstrated enhanced therapeutic efficacy in the 9AA-SAA hydrogel, significantly reducing the severity of experimental arthritis. This approach, in contrast to existing treatments with limited effectiveness, presents a promising and more effective strategy for RA treatment by mitigating inflammation in experimental arthritis.