<i>Gnetum montanum</i> extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells
Xianglong Pan, Xiaotao Hou, Fan Zhang, Pei Ling Tang, Wanruo Wan, Zixia Su, Yeguo Yang, Wei Wei, Zhengcai Du, Jiagang Deng, Erwei Hao
Abstract
CONTEXT: Markgr. (Gnetaceae) is used to treat rheumatic arthralgia and bruises in the clinic. OBJECTIVE: extract (GME) against colon cancer cells SW480. MATERIALS AND METHODS: activity of GME was evaluated using xenograft tumour model of zebrafish and nude mice. The chemical composition of GME was detected by using HPLC-MS/MS. RESULTS: < 0.01) at 56 mg/kg/day. Forty-two compounds were identified from the GME. DISCUSSION AND CONCLUSIONS: GME has a significant antitumor effect on colon cancer cells SW480, and it has the potential to be developed as an anticancer agent.
Topics & Concepts
ApoptosisIn vivoFlow cytometryProtein kinase BChemistryIn vitroMolecular biologyIC50PharmacologyBiologyBiochemistryBiotechnologyCancer Mechanisms and TherapyCell death mechanisms and regulationNatural Compounds in Disease Treatment