Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner
Rohit Singh, James W. McNamara, Sakthivel Sadayappan
Abstract
showed increased the rate of force redevelopment. In summary, S2 and C0-C2 interaction mediated by phosphorylation is altered by mutations in S2, which augment the speed and force of contraction observed in HCM. Modulating this interaction could be a potential strategy to treat HCM in the future.
Topics & Concepts
Hypertrophic cardiomyopathyPhosphorylationMyosinMYH6CardiomyopathyCardiac muscleChemistryMYH7Cell biologyMyosin light-chain kinaseInternal medicineBiologyEndocrinologyMedicineBiochemistryHeart failureCardiomyopathy and Myosin StudiesViral Infections and Immunology ResearchCardiovascular Effects of Exercise