Systematic synthesis of bisected <i>N</i>-glycans and unique recognitions by glycan-binding proteins
Xuefeng Cao, Shuaishuai Wang, Madhusudhan Reddy Gadi, Ding Liu, Peng George Wang, Xiu‐Feng Wan, Jian Zhang, Xi Chen, Lauren E. Pepi, Parastoo Azadi, Lei Li
Abstract
A library of bisected N -glycans was chemoenzymatically synthesized and used to fabricate a unique bisected/non-bisected glycan microarray. The effect of the bisecting GlcNAc in glycan recognition by glycan-binding proteins was interpreted with this array.
Topics & Concepts
GlycanChemistryComputational biologyBiochemistryBiologyGlycoproteinGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisProteoglycans and glycosaminoglycans research