Novel Hsp90-Targeting PROTACs: Enhanced synergy with cisplatin in combination therapy of cervical cancer
Jinsen Liang, Dandan Wang, Yijin Zhao, Yihe Wu, Xuelian Liu, Lilan Xin, Junhong Dai, Hang Ren, Hai‐Bing Zhou, Hongbing Cai, Chune Dong
Topics & Concepts
CisplatinCombination therapyPI3K/AKT/mTOR pathwayChemistryApoptosisIn vivoPharmacologyCervical cancerCancer cellProtein kinase BCancerMetastasisCancer researchHsp90Cell cycle checkpointCancer therapyCell cycleChemotherapyMedicineInternal medicineBiochemistryBiologyBiotechnologyHeat shock proteinGenePeptidase Inhibition and AnalysisUbiquitin and proteasome pathwaysSignaling Pathways in Disease