Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy
Valerie J. Carpenter, Tareq Saleh, So Min Lee, Graeme Murray, Jason Reed, Andrew J. Souers, Anthony C. Faber, Hisashi Harada, David A. Gewirtz
Topics & Concepts
Prostate cancerCancer researchSenescenceAndrogen deprivation therapyAndrogenBiologyBicalutamideStathminCancerInternal medicineAndrogen receptorEndocrinologyMedicineCell biologyHormonePhosphorylationTelomeres, Telomerase, and SenescenceImmunotherapy and Immune ResponsesCancer-related Molecular Pathways