Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells
Antti Rahikkala, Flavia Fontana, Tomás Bauleth‐Ramos, Alexandra Correia, Marianna Kemell, Jani Seitsonen, Ermei Mäkilä, Bruno Sarmento, Jarno Salonen, Janne Ruokolainen, Jouni Hirvonen, Hélder A. Santos
Abstract
We report a study on the effect of red blood cell membrane based cancer antigen-functionalized nanoparticles on peripheral blood T cells. These nanoparticles induce apoptosis of T cells and they may have use in treating autoimmune diseases.
Topics & Concepts
Cytotoxic T cellBiocompatibilityCD8ChemistryMembraneAntigenCancer cellT cellRed blood cellImmune systemBiophysicsMaterials scienceImmunologyCancerMedicineBiochemistryBiologyIn vitroOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsExtracellular vesicles in diseaseNanoparticle-Based Drug Delivery