Effects of Low-level Lipid Peroxidation on the Permeability of Nitroaromatic Molecules across a Membrane: A Computational Study
Hong Yang, Mi Zhou, Huarong Li, Tong Wei, Can Tang, Yang Zhou, Xinping Long
Abstract
). The result suggests that the membrane permeability can be greatly promoted in the physiologically relevant environment with low-level LPO, and more importantly, clarifies the contributions of both the hydrophobicity of the membrane interior and the structural feature of solutes to such enhanced permeability. This work may provide significant insight into the toxic effects of nitroaromatic molecules and the pharmaceutical characteristics of tissues with oxidative damage.
Topics & Concepts
MembraneChemistryBiophysicsLipid bilayerLipid peroxidationHydrogen bondPermeability (electromagnetism)BilayerMolecular dynamicsMoleculeMembrane permeabilityBiochemistryOxidative stressComputational chemistryOrganic chemistryBiologyLipid Membrane Structure and BehaviorMolecular Sensors and Ion DetectionSurfactants and Colloidal Systems