Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition
Iuliana Besleaga, I.N. Stepanenko, Tatsiana V. Petrasheuskaya, Denisa Darvasiová, Martin Breza, Marta Hammerstad, Małgorzata Anna Marć, Alexander Roller, Gabriella Spengler, Ana Popović‐Bijelić, Éva A. Enyedy, Peter Rapta, Anatoly D. Shutalev, Vladimir B. Arion
Abstract
in the presence of 1,4-dithiothreitol are as potent inhibitors of mR2 ribonucleotide reductase as triapine.
Topics & Concepts
ChemistryRedoxCopperLigand (biochemistry)ElectrochemistryMetalMedicinal chemistryAqueous solutionInorganic chemistryIminePhotochemistryStereochemistryOrganic chemistryCatalysisElectrodeReceptorBiochemistryPhysical chemistryMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryMetal-Organic Frameworks: Synthesis and Applications