Lung Pathology of COVID-19 in Moscow
М. В. Самсонова, L.M. Mikhalyova, O. V. Zairatyants, V.V. Varyasin, A. V. Bykanova, Mishnev Od, Yu.S. Berezovsky, O.A. Tishkevitch, E.A. Gomzikova, A. L. Chernyayev, T.N. Khovanskaya
Abstract
We analyzed lung material from 22 dead obtained on autopsy for the period from March, 6 to April,30, 2020, in various clin-ics in Moscow For this period died 532 patients (219 female, 324 male),with mean age 67 47±14 67 years In all 22 deceased patients, the diagnosis of COVID-19 was confirmed in vivo (PCR study on material from the nasopharynx, in some patients by a positive PCR analysis in material obtained from trachea and lung tissue during autopsy) The average age of these deceased was 72 27±10 74 years, the duration of the disease ranged from 5 to 32 days In severe COVID-19, patients develop viral interstitial pneumonia with the development of diffuse alveolar damage, which causes a severe course of the disease, hypoxia, and respiratory failure An incomplete correspondence was found between morphological changes in the lungs (phases of diffuse alveolar damage) and the duration of the disease, which is most likely due to the unspecified duration of the asymptomatic course in many patients The course of a new coronavirus infection is characterized by primary damage to the lungs, an increase in hemoglobin concentration in the blood, a decrease in SpO2, lymphopenia with a simultaneous increase in leukocytosis, and signs of hyperco-agulation in extremely severe patients Virus-bacterial pneumonia may occur mainly in individuals with tracheal intubation, with tracheostomy and prolonged mechanical ventilation on any stage of the disease © 2020, Media Sphera Publishing Group All rights reserved