Site-Selective Binding of Peripheral Chiral Guests Induces Stereospecificity in A<sub>4</sub>L<sub>6</sub> Tetrahedral Anion Cages
Boyang Li, Bo Zheng, Wenyao Zhang, Dan Zhang, Xiao‐Juan Yang, Biao Wu
Abstract
-β-methylcholine, which are bound along the tetrahedral edges in a highly site-specific fashion. This "peripheral templation", which has proven indispensable for the formation of tetrahedral structure, is also an effective approach to encoding chiral information to the tetrahedron. Moreover, the site-selective binding of chiral choline derivatives to the anion cage with induced one-handedness may imply applications of such metal-free, labile systems in the study of biological processes such as selective recognition of structurally similar molecules.
Topics & Concepts
ChemistryTetrahedronIonStereospecificityStereochemistryMoleculeTetrahedral molecular geometryCrystallographyTetrahedral carbonyl addition compoundOrganic chemistryNucleophileCatalysisMolecular Sensors and Ion DetectionSupramolecular Chemistry and ComplexesCrystallography and molecular interactions