The Antimalaria Drug Artesunate Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Activating AMPK and Nrf2/HO-1 Signaling Pathways
Feixiang Long, Mingxin Zhang, Xia Yang, Xiaohuan Liang, Lizhan Su, Tongqing An, Guihong Zhang, Zhenling Zeng, Yahong Liu, Weisan Chen, Jianxin Chen
Abstract
primary porcine alveolar macrophages (PAMs). Furthermore, we demonstrate that AS inhibits PRRSV replication via activation of AMPK-dependent Nrf2/HO-1 signaling pathways, revealing a novel link between energy homeostasis (AMPK) and inflammation suppression (Nrf2/HO-1) during viral infection. Therefore, we believe that AS may be a promising novel therapeutics for controlling PRRSV, and its anti-PRRSV mechanism may provide a strategy to develop novel antiviral agents.
Topics & Concepts
Porcine reproductive and respiratory syndrome virusAMPKBiologyViral replicationArtesunateVirologyPharmacologyDrugVirusAntiviral drugImmunologySignal transductionInflammationDrug discoveryAMP-activated protein kinaseRespiratory systemCell biologyVaccinationAdenosineAnimal Virus Infections StudiesMetabolism, Diabetes, and CancerGenomics, phytochemicals, and oxidative stress