Paeoniflorin Attenuates Myocardial Ischemia / Reperfusion Injury via Up-Regulation of Notch 1 Mediated Jagged1 Signaling
Nasser Ghaly Yousif, Zahraa Younis, Fadhil G. Al-Amran, Maitham G. Yousif, Ahmed Altimim, Najah R. Hadi
Abstract
Ischemic heart disease represents one of the major reasons of death worldwide. Methods and materials: A total number of 48 mice were assigned to one of the following 4 experimental groups (n = 8 in each group); sham; control I/R; I/R + vehicle group and I/R + Paeoniflorin pretreated group treated with (5 mg/kg intraperitoneal dose of PF) 30 min before ischemia and underwent 30 minute of LAD ligation followed by 72 hours reperfusion. After analysis of cardiac function, the heart tissue and blood were collected and prepared for analysis. Results: The % FS was significantly higher at 3 days after surgery in Paeoniflorin treated mice than I/R control and vehicle treated mice. Paeoniflorin treated mice had lower levels of MCP-1 in myocardial tissue and plasma P