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Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway

Yijing Zhao, Changhong He, Shaozhen Hu, H. Ni, Xiaoqin Tan, Yingkun Zhi, Lang Yi, Risong Na, Yanwu Li, Qun Du, Qing X. Li, Dong Yan

2024Experimental Neurology22 citationsDOI

Topics & Concepts

IsoorientinGSK-3Oxidative stressNeurosciencePathogenesisProtein kinase BPharmacologyGlycogen synthaseMedicineSignal transductionChemistryBiologyEndocrinologyInternal medicineBiochemistryFlavonoidGlycogenAntioxidantAlzheimer's disease research and treatmentsGenomics, phytochemicals, and oxidative stressDementia and Cognitive Impairment Research
Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway | Litcius