Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions
G. Huang, Claribel Murillo-Solano, Joel Castillo Melendez, Sabrina Yu-Alfonzo, Rachasak Boonhok, Hui Min, Jun Miao, Debopam Chakrabarti, Yu Yuan
Topics & Concepts
ChemistryPlasmodium falciparumChemical spaceLead compoundAntimalarial AgentAzideCombinatorial chemistryAlkyneStereochemistryDrug discoveryIn vitroBiochemistryMalariaCatalysisBiologyOrganic chemistryImmunologyClick Chemistry and ApplicationsHIV/AIDS drug development and treatmentSynthesis and Catalytic Reactions