Redox-Neutral Site-Selective C–H Allylation and Iodolactonization of Benzoic Acids Using Morita–Baylis–Hillman Adducts in Water
Hemanga Bhattacharyya, Sharajit Saha, Kshitiz Verma, Tharmalingam Punniyamurthy
Abstract
A Ru-catalyzed carboxylate directed C-H allylation and iodolactonization of benzoic acids has been accomplished with Morita-Baylis-Hillman adducts as the coupling partner in environmentally benign water as solvent. The redox-neutral conditions, use of water as a solvent, substrate scope, functional group tolerance, and mutation of natural products and drug molecules are the important practical features.
Topics & Concepts
ChemistryAdductCarboxylateBenzoic acidRedoxSolventSubstrate (aquarium)StereochemistryOrganic chemistryOceanographyGeologyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques