A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein
Yanyan Zhao, Ole Tietz, Wei‐Li Kuan, Abdul Karim Haji Dheere, Stephen Thompson, Benjamin Vallin, Elisabetta Ronchi, Gergely Tóth, David Klenerman, Franklin I. Aigbirhio
Abstract
<bold>pTP-TFE</bold> imaging probe can distinguish soluble tau aggregated proteins from other aggregated proteins enabling earlier detection of neurodegenerative diseases.
Topics & Concepts
FluorescenceChemistryMolecular imagingSelectivityFluorescent proteinBiophysicsNanotechnologyGreen fluorescent proteinBiochemistryMaterials scienceBiologyGenePhysicsGeneticsIn vivoCatalysisQuantum mechanicsAlzheimer's disease research and treatmentsProtein Structure and DynamicsS100 Proteins and Annexins