Insights into stimuli-responsive diselenide bonds utilized in drug delivery systems for cancer therapy
Zhenfeng Shi, Jifang Liu, Lei Tian, Jingyi Li, Yue Gao, Yue Xing, Wenjing Yan, Chen-Yu Hua, Xiaolin Xie, Chang Liu, Chengyuan Liang
Abstract
Due to the complexity and particularity of cancer cell microenvironments, redox responsive drug delivery systems (DDSs) for cancer therapy have been extensively explored. Compared with widely reported cancer treatment systems based on disulfide bonds, diselenide bonds have better redox properties and greater anticancer efficiency. In this review, the significance and application of diselenide bonds in DDSs are summarized, and the stimulation sensitivity of diselenide bonds is comprehensively reported. The potential and prospects for the application of diselenide bonds in next-generation anticancer drug treatment systems are extensively discussed.