IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells
Timuçin Avşar, Tansu Bilge Kose, Muhammed Deniz Oksal, Gizem Turan, Türker Kılıç
Topics & Concepts
PI3K/AKT/mTOR pathwayGliomaCell growthIsocitrate dehydrogenaseBiologyIDH1Cancer researchCarcinogenesisProtein kinase BSignal transductionMutationMutantTransfectionDownregulation and upregulationCell cultureCell biologyCancerGeneGeneticsBiochemistryEnzymeGlioma Diagnosis and TreatmentCancer Research and TreatmentCaveolin-1 and cellular processes