A focus on sustainable method development for greener synthesis
Jasper L. Tyler, Felix Katzenburg, Frank Glorius
Abstract
, 6399, https://doi.org/10.1039/D3SC01699D) have succinctly demonstrated how employing more sustainable methodology can vastly reduce the environmental impact associated with the synthesis of the antimalarial drug candidate MMV688533. The most notable feature of this newly reported synthetic route is the application of aqueous micellar conditions to two Sonogashira coupling reactions that simultaneously improve the yield, catalyst loading and sustainability of these key steps.
Topics & Concepts
Focus (optics)Sustainable developmentBiochemical engineeringProcess managementNanotechnologyComputer scienceBusinessChemistryEngineeringPolitical scienceMaterials sciencePhysicsOpticsLawChemistry and Chemical EngineeringProcess Optimization and IntegrationCarbon dioxide utilization in catalysis