Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme

John Blazeck, Christos S. Karamitros, Kyle Ford, Catrina M. Somody, Ahlam N. Qerqez, Kyle Murray, Nathaniel T. Burkholder, Nicholas Marshall, Anirudh Sivakumar, Weicheng Lu, Bing Tan, Candice Lamb, Yuri Tanno, M Siddiqui, Norah E Ashoura, Sílvia Coma, Xiaoyan M. Zhang, Karen McGovern, Yoichi Kumada, Yan Zhang, Mark Manfredi, Kenneth A. Johnson, Sheena D’Arcy, Everett Stone, George Georgiou