Development and optimization of a LC-MS/MS compatible method for quantification of losartan, hydrochlorothiazide and their impurities using AQbD approach and measurement uncertainty evaluation
Ariel Lucas Rocha, Felipe Rebello Lourenço
Topics & Concepts
ChemistryLosartan PotassiumHydrochlorothiazideDesign of experimentsChromatographyCentral composite designQuality by DesignResponse surface methodologyLosartanProcess engineeringAngiotensin IIStatisticsMathematicsEngineeringPhysical chemistryMedicineReceptorParticle sizeBiochemistryBlood pressureRadiologyAnalytical Methods in PharmaceuticalsPesticide Residue Analysis and SafetyAnalytical Chemistry and Chromatography