Design, synthesis, and biological evaluation of trizole-based heteroaromatic derivatives as Bcr-Abl kinase inhibitors
Xiaoyan Pan, Nanxin Liu, Yuying Liu, Qingqing Zhang, Kai Wang, Xueying Liu, Jie Zhang
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ChemistryK562 cellsABLImatinibKinaseADMEIC50breakpoint cluster regionDocking (animal)Chronic myelogenous leukemiaPharmacologyBiochemistryApoptosisLeukemiaIn vitroCancer researchSignal transductionTyrosine kinaseReceptorMyeloid leukemiaBiologyGeneticsMedicineNursingChronic Myeloid Leukemia TreatmentsQuinazolinone synthesis and applicationsClick Chemistry and Applications