Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models
Lu Yu, Xiaoli Zhang, Yexin Yang, Dan Li, Kaiyuan Tang, Zifan Zhao, Wanwan He, Ce Wang, Nirakar Sahoo, Kimber Converso‐Baran, Carol Davis, Susan V. Brooks, Anne Bigot, Raul Calvo, Natalia J. Martinez, Noel Southall, Xin Hu, Juan Marugán, Marc Ferrer, Haoxing Xu
Abstract
channels may represent a promising approach to treat DMD and related muscle diseases.
Topics & Concepts
Duchenne muscular dystrophyMuscular dystrophyDystrophinCell biologyMedicineChemistryBiologyNeuroscienceGeneticsCalcium signaling and nucleotide metabolismIon Channels and ReceptorsSirtuins and Resveratrol in Medicine