Molecular Mechanisms of Drug Resistance in Glioblastoma
М. А. Дымова, Elena V. Kuligina, Vladimir A. Richter
Abstract
Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not amenable to effective surgical resection. The present review summarizes recent advances in our understanding of the molecular mechanisms of therapeutic resistance of GBM to already known drugs, the molecular characteristics of glioblastoma cells, and the barriers in the brain that underlie drug resistance. We also discuss the progress that has been made in the development of new targeted drugs for glioblastoma, as well as advances in drug delivery across the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB).
Topics & Concepts
GlioblastomaBlood–brain barrierDrug resistanceBrain tumorDrugMedicineDrug deliveryBrain cancerChemotherapyTemozolomideRadiation therapyCancer researchBiologyPathologyPharmacologyCentral nervous systemCancerInternal medicineChemistryMicrobiologyOrganic chemistryGlioma Diagnosis and TreatmentDrug Transport and Resistance MechanismsBarrier Structure and Function Studies